The trade-off is performance. Every syscall goes through user-space interception, which adds overhead. I/O-heavy workloads feel this the most. For short-lived code execution like scripts and tests, it is usually fine, but for sustained high-throughput I/O, it can matter.
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Intrinsic was started in 2021 as an Alphabet "Other Bets" project, part of a portfolio of high-risk and potentially high-payoff startups, Waymo among them. The project will now run as a "distinct group" within Google where it will leverage Gemini and Google Cloud while working closely with the Google DeepMind team.